tailieunhanh - Clinical response of newly diagnosed HIV seropositive & seronegative pulmonary tuberculosis patients with the RNTCP Short Course regimen in Pune, India

All HIV seronegative smear positive TB patients received category I regimen while the smear negative patients were treated with the category III regimens as per the guidelines of the RNTCP. The patients were treated with an initial intensive phase lasting for 2 months followed by a continuation phase, which lasted for 4 months. In the intensive phase, three to four anti-TB drugs were administered thrice weekly depending on the category of treatment prescribed; all the thrice weekly doses were given under direct observation. In the continuation phase, the number of anti-TB drugs administered was reduced to two and only the first. | Indian J Med Res 133 May 2011 pp 521-528 Clinical response of newly diagnosed HIV seropositive seronegative pulmonary tuberculosis patients with the RNTCP Short Course regimen in Pune India S. Tripathy A. Anand V. Inamdar . Manoj . Khillare . Datye R. Iyer . Kanoj M. Thakar V. Kale M. Pereira . Risbud National AIDS Research Institute ICMR Talera Hospital Pimpri Chichwad Municipal Corporation Pune India Received January 27 2010 Background objectives In the Revised National Tuberculosis Control Programme RNTCP in India prior to 2005 TB patients were offered standard DOTS regimens without knowledge of HIV status. Consequently such patients did not receive anti-retroviral therapy ART and the influence of concomitant HIV infection on the outcome of anti-tuberculosis treatment remained undetermined. This study was conducted to determine the results of treatment of HIV seropositive pulmonary tuberculosis patients with the RNTCP DOTS regimens under the programme in comparison with HIV negative patients prior to the availability of free ART in India. Methods Between September 2000 and July 2006 283 newly diagnosed pulmonary TB patients were enrolled in the study at the TB Outpatient Department at the Talera Hospital in the Pimpri Chinchwad Municipal Corporation area at Pune Maharashtra they included 121 HIV seropositive and 162 HIV seronegative patients. They were treated for tuberculosis as per the RNTCP in India. This study was predominantly conducted in the period before the free ART become available in Pune. Results At the end of 6 months of anti-TB treatment 62 per cent of the HIV seropositive and 92 per cent of the HIV negative smear negative patients completed treatment and were asymptomatic among smear positive patients 70 per cent of the HIV-seropositive and 81 per cent of HIV seronegative pulmonary TB patients were cured. Considering the results in the smear positive and smear negative cases together treatment success rates were substantially lower

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