tailieunhanh - Pulmonary Tuberculosis in Patients with HIV/AIDS in Iran

A pre-tested questionnaire was used by a trained counselor to obtain information on demographic characteristics, social and medical history from the subjects. Other important information about PTB such as previous BCG vaccination, contact with an index case and exposure to tuberculin skin test were also obtained. Laboratory investigations: Three early morning sputum were collected from each consenting asymptomatic subject. The samples were transported to TB laboratory of the department of Medical Microbiology and Parasitology, UCH, for immediate processing. Each sample was smeared, air-dried, fixed and stained with Z-N reagents. The staining procedure was controlled by using known AFB slide and slide stained with egg albumin as positive and negative controls respectively | Iranian J Publ Health Vol. 40 2011 pp. 100-106 Original Article Pulmonary Tuberculosis in Patients with HIV AIDS in Iran A Hadadi1 P Tajik 2 M Rasoolinejad 3 S Davoudi3 M Mohraz 3 1Dept. of Infectious Diseases Sina Hospital Iranian Research Center for HIV AIDS Tehran University of Medical Sciences Tehran Iran 2Dept. of Epidemiology Biostatistics School of Public Health Tehran University of Medical Sciences Tehran Iran 3Dept. of Infectious Diseases Research Center for HIV AIDS Imam Khomeini Hospital Tehran University of Medical Sciences Tehran Iran Received 5 Jul 2010 accepted 12 Feb 2011 Abstract Background Pulmonary tuberculosis is still the most common form of tuberculosis in HIV infected patients having different presentations according to the degree of immunosuppression. This study appraised the impact of HIV infection on clinical laboratory and radiological presentations of tuberculosis. Methods The clinical laboratory and radiological presentations of pulmonary TB in 56 HIV-infected patients were compared with 56 individually sex and age matched HIV-seronegative ones admitted to Imam Hospital in Tehran 1999-2006 using paired t-test in a case control study. Results All cases and the controls were male. Fever was found in of the HIV positive patients compared to 80 of the HIV negative ones. Cough was the most common clinical finding in the HIV negative group vs. in HIV positive group . Among radiological features cavitary lesions upper lobe and bilateral pulmonary involvement were observed significantly less often in the HIV-infected group. On the contrary lymphadenopathy was just present in the HIV positive group in this series of patients 12 and primary pattern tuberculosis was more common as well 71 vs. 39 P . The Tuberculin test was reactive in 29 of the HIV TB patients. Conclusion The coexistence of both infections alters the picture of tuberculosis in many aspects and should be taken into account when considering a diagnosis of .