tailieunhanh - báo cáo khoa hoc : Identification and verification of heat shock protein 60 as a potential serum marker for colorectal cancer

Colorectal cancer (CRC) is a major public health issue worldwide, and novel tumor markers may contribute to its efficient management by helping in early detection, prognosis or surveillance of disease. The aim of our study was to identify new serum biomarkers for CRC, and we followed a phased biomarker discovery and validation process to obtain an accurate preliminary assessment of potential clinical utility. | IFEBS Journal Identification and verification of heat shock protein 60 as a potential serum marker for colorectal cancer Celine Hamelin1 Emilie Cornut2 Florence Poirier1 3 Sylvie Pons1 Corinne Beaulieu1 loan-PHilinno Harrior1 I I a dor I la irlo I IQ4 PHH r i o5 6 1 a I ido I amKor 7 Pranooieo Piarrl2 Jean ppe caiiiei adei aidous ddy cone Claude amueii lani oise aid Yasemin Ataman-Onal1 and Genevieve Choquet-Kastylevsky1 1 Immunoproteomics Laboratory Department of Biomarkers bioMerieux Marcy I etoile France 2 Department of Anatomo-pathology Dijon University Hospital France 3 University of Paris 13 CNRS CSPBAT LBPS Bobigny France 4 Department of Clinical Trials bioMerieux Marcy l etoile France 5 Department of SurgicalOncology Lyon Sud University Hospital Pierre Benite France 6 University of Lyon I EMR 3738 Oullins France 7 Immunology Laboratory Saint-Etienne University Hospital Center for Health Engineering UMR-CNRS 5148 LPMG and IFR 143 INSERM IFRESIS France Keywords 2D-DIGE colorectalcancer HSP60 marker validation serum biomarker Correspondence G. Choquet-Kastylevsky Immunoproteomics Laboratory Department of Biomarkers bioMerieux Chemin de l Orme 69280 Marcy l etoile France Fax 33 478 872 101 Tel 33 478 877 599 E-mail Re-use of this article is permitted in accordance with the Terms and Conditions set out at http onlineopen OnlineOpen_Terms Received 11 August 2011 revised 20 September 2011 accepted 21 September 2011 doi Colorectal cancer CRC is a major public health issue worldwide and novel tumor markers may contribute to its efficient management by helping in early detection prognosis or surveillance of disease. The aim of our study was to identify new serum biomarkers for CRC and we followed a phased biomarker discovery and validation process to obtain an accurate preliminary assessment of potential clinical utility. We compared colonic tumors and matched normal tissue from