tailieunhanh - báo cáo hóa học:" Mapping of the EQ-5D index from clinical outcome measures and demographic variables in patients with coronary heart disease"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Mapping of the EQ-5D index from clinical outcome measures and demographic variables in patients with coronary heart disease | Goldsmith et al. Health and Quality of Life Outcomes 2010 8 54 http content 8 1 54 I HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Mapping of the EQ-5D index from clinical outcome measures and demographic variables in patients with coronary heart disease Kimberley A Goldsmith 1 2 3 Matthew T Dyer4 5 Martin J Buxton4 and Linda D Sharpies1 2 Abstract Background The EuroQoL 5D EQ-5D is a questionnaire that provides a measure of utility for cost-effectiveness analysis. The EQ-5D has been widely used in many patient groups including those with coronary heart disease. Studies often require patients to complete many questionnaires and the EQ-5D may not be gathered. This study aimed to assess whether demographic and clinical outcome variables including scores from a disease specific measure the Seattle Angina Questionnaire SAQ could be used to predict or map the EQ-5D index value where it is not available. Methods Patient-level data from 5 studies of cardiac interventions were used. The data were split into two groups -approximately 60 of the data were used as an estimation dataset for building models and 40 were used as a validation dataset. Forward ordinary least squares linear regression methods and measures of prediction error were used to build a model to map to the EQ-5D index. Age sex a proxy measure of disease stage Canadian Cardiovascular Society CCS angina severity class treadmill exercise time ETT and scales of the SAQ were examined. Results The exertional capacity ECS disease perception DPS and anginal frequency scales AFS of the SAQ were the strongest predictors of the EQ-5D index and gave the smallest root mean square errors. A final model was chosen with age gender disease stage and the ECS DPS and AFS scales of the SAQ. ETT and CCS did not improve prediction in the presence of the SAQ scales. Bland-Altman agreement between predicted and observed EQ-5D index values was reasonable for values greater than but below this level .