tailieunhanh - Báo cáo y học: " Pandemic 2009 H1N1 virus infection associated with purpuric skin lesions: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Pandemic 2009 H1N1 virus infection associated with purpuric skin lesions: a case report. | Urso et al. Journal of Medical Case Reports 2011 5 132 http content 5 1 132 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Pandemic 2009 H1N1 virus infection associated with purpuric skin lesions a case report Rocco Urso1 Nazario Bevilacqua1 Marco Gentile2 Daniele Biagioli1 and Francesco Nicola Lauria1 Abstract Introduction The influenza virus infection may be severe in non-immune people. Common complications of influenza virus include upper and lower respiratory tract infections otitis media myocarditis acute respiratory distress syndrome and multi-organ failure. There have been cases of vasculitis following influenza vaccination and rash and acute purpura may occur in certain viral infections. To the best of our knowledge there are no reports concerning cases of systemic vasculitis associated with pandemic 2009 H1N1 infection. Case presentation A 23-year-old Caucasian woman was hospitalized at the L. Spallanzani National Institute for Infectious Diseases in Rome Italy. Clinical and radiological features including laboratory findings of this case are illustrated. Notably the patient had fever severe abdominal pain hematuria arthritis and purpuric manifestations associated with a normal platelet count. Nasopharyngeal and rectal swabs revealed pandemic 2009 H1N1 virus by reverse-transcriptase-polymerase-chain-reaction assay. Routine laboratory analyses showed elevated inflammatory parameters. The autoimmune panel tests were normal. Steroid therapy associated with oseltamivir achieved an evident and rapid improvement. On day seven the patient chose to leave the hospital against medical advice. Conclusion Complications related to influenza infection can be life threatening particularly in immunocompromised patients. Henoch-Schonlein purpura triggered by the novel influenza virus infection could be an attractive pathogenetic hypothesis. We have discussed both the diagnosis and the challenge of therapy protocols. Steroid therapy is .