tailieunhanh - báo cáo hóa học: " Heath-related quality of life in thyroid cancer patients following radioiodine ablation"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Heath-related quality of life in thyroid cancer patients following radioiodine ablation | Taĩeb et al. Health and Quality of Life Outcomes 2011 9 33 http content 9 1 33 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Heath-related quality of life in thyroid cancer patients following radioiodine ablation 1 2 3 2 4 David Taieb Karine Baumstarck-Barrau Frédéric Sebag Cécile Fortanier Catherine De Micco Anderson Loundou2 Pascal Auquier5 Fausto F Palazzo3 Jean-frangois Henry3 and Olivier Mundler1 Abstract Background There is limited information about the medium to long-term health-related quality of life QOL in thyroid cancer patients after initial therapy and the existing studies suffer from limitations. The aim of the study was to assess the determinants of medium-term QOL after the initial therapy. Methods Following a total thyroidectomy 88 thyroid cancer patients received either rhTSH or hypothyroid-assisted radioiodine ablation RRA using GBq 100 mCi of radioiodine. QOL evaluation of the patients using the validated Functional Assessment of Chronic Illness Therapy FACIT was performed at the time of inclusion to and later at the 9-month post-RRA t1 . Results 83 patients were eligible for the final evaluation. Medium-term FACIT scores were not statistically different between to and t1 patients. All but one domain of the QOL score was similar between to and t1. Using a multivariate analysis only age and immediate postoperative QOL scores were found to be determinants of the overall medium term 9-month QOL scores. Analysis showed that high QOL levels baseline and 9-month and no depression low anxiety levels were associated with 45yrs men partner and rhTSH stimulation . Conclusions The use of radioiodine ablation does not seem to affect the medium term QOL scores of patients. Medium-term QOL is mainly determined by pre-ablation QOL. The assessment of baseline QOL might be interesting to evaluate in order to adapt the treatment protocols the preventive strategies and medical information to patients for potentially improving their .