tailieunhanh - Báo cáo y học: "Quinupristin/dalfopristin in Staphylococcus aureus endophthalmitis: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Quinupristin/dalfopristin in Staphylococcus aureus endophthalmitis: a case report. | Hernandez-Da Mota Journal of Medical Case Reports 2011 5 130 http content 5 1 130 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Quinupristin dalfopristin in Staphylococcus aureus endophthalmitis a case report Sergio E Hernandez-Da Mota Abstract Introduction The intravitreal injection of antibiotics remains the mainstay of therapy for postoperative endophthalmitis. Bacterial resistance however is still a pitfall in achieving an adequate response to treatment. Quinupristin dalfopristin might be a feasible therapeutic option in these cases. Case presentation A 55-year-old Hispanic man had endophthalmitis secondary to Staphylococcus aureus in his right eye and was treated with intravitreal mg ml quinupristin dalfopristin injection. Inflammation and pain remission were observed at four days after injection. The final best-corrected visual acuity was 20 40. Conclusion Although vancomycin remains the first-line intravitreal antibiotic therapy against infectious endophthalmitis caused by Gram-positive bacteria quinupristin dalfopristin exhibits similar efficacy and is theoretically more active against vancomycin-resistant strains with no apparent retinal toxicity. Introduction Postoperative endophthalmitis has been a major and dreaded complication in all types of eye surgery. Several measures have been used for its prevention such as aseptic techniques and topical prophylactic antibiotics. Although these measures have resulted in very low endophthalmitis incidence 1 they have not been able to eliminate it completely. Once infection is identified the mainstay of therapy has been the intravitreal injection of antibiotics 2 . The concomitant use of pars plana vitrectomy and steroids has also been recommended 3 in some cases. The most common bacterial etiology of the disease involves Gram-positive bacteria especially Staphylococci. Vancomycin a glucopeptide antibiotic has shown adequate activity against this type of bacteria 4 . .