tailieunhanh - báo cáo khoa học: "Microfluidics in biotechnology"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Microfluidics in biotechnology | Journal of Nanobiotechnology BioMed Central Review Microfluidics in biotechnology Richard Barry 1 and Dimitri Ivanov2 Open Access Address 1School of Biological Sciences Royal Holloway University of London Egham Surrey TW20 0EX United Kingdom and 2 Laboratoire de Physique des Polymères CP223 Université Libre de Bruxelles B-1050 Brussels Belgium Email Richard Barry - Dimitri Ivanov - divanov@ Corresponding author Published 31 March 2004 Received 04 December 2003 Accepted 31 March 2004 Journal of Nanobiotechnology 2004 2 2 This article is available from http content 2 l 2 2004 Barry and Ivanov licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Microfluidics enables biotechnological processes to proceed on a scale microns at which physical processes such as osmotic movement electrophoretic-motility and surface interactions become enhanced. At the microscale sample volumes and assay times are reduced and procedural costs are lowered. The versatility of microfluidic devices allows interfacing with current methods and technologies. Microfluidics has been applied to DNA analysis methods and shown to accelerate DNA microarray assay hybridisation times. The linking of microfluidics to protein analysis techologies . mass spectrometry enables picomole amounts of peptide to be analysed within a controlled micro-environment. The flexibility of microfluidics will facilitate its exploitation in assay development across multiple biotechnological disciplines. Background Current analytical techniques in biotechnology can potentially benefit from an integrated reduction in scale through lowered production and operating costs and via the specific dynamics of flowing fluids occurring at the mico-scale which enable the generation of accurate