tailieunhanh - Báo cáo y học: " Prenatal exposure of a girl with autism spectrum disorder to ‘horsetail’ (Equisetum arvense) herbal remedy and alcohol: a case repor"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prenatal exposure of a girl with autism spectrum disorder to ‘horsetail’ (Equisetum arvense) herbal remedy and alcohol: a case report. | Ortega García et al. Journal of Medical Case Reports 2011 5 129 http content 5 1 129 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Prenatal exposure of a girl with autism spectrum disorder to horsetail Equisetum arvense herbal remedy and alcohol a case report IA 1 1 1 2 3 Juan A Ortega García Mario G Angulo Elias J Sobrino-Najul Offie P Soldin Alberto Puche Mira Eduardo Martínez-Salcedo3 and Luz Claudio4 Abstract Introduction Autism is a complex neurodevelopmental disorder in which the interactions of genetic epigenetic and environmental influences are thought to play a causal role. In humans throughout embryonic and fetal life brain development is exquisitely susceptible to injury caused by exposure to toxic chemicals present in the environment. Although the use of herbal supplements during pregnancy is relatively common little information is available on their association with fetal neurodevelopment. This is to the best of our knowledge the first report in the literature to associate a new plausible mechanism of neurodevelopmental toxicity with a case of autism spectrum disorder through a vitamin deficiency potentiated by concomitant use of herbal supplements and ethanol exposure. Case presentation We describe the pediatric environmental history of a three-year-old Caucasian girl with an autism spectrum disorder. We utilized her pediatric environmental history to evaluate constitutional genetic and environmental factors pertinent to manifestation of neurodevelopment disorders. Both parents reported prenatal exposure to several risk factors of interest. A year prior to conception the mother began a weight loss diet and ingested 1200 mg day of horsetail Equisetum arvense herbal remedies containing thiaminase an enzyme that with long-term use can lead to vitamin deficiency. The mother reported a significant weight loss during the pregnancy and a deficiency of B-complex vitamins. Thiamine vitamin B1 deficiency could have .