tailieunhanh - báo cáo hóa học: " Comparison of health-related quality of life measures in chronic obstructive pulmonary disease"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Comparison of health-related quality of life measures in chronic obstructive pulmonary disease | Pickard et al. Health and Quality of Life Outcomes 2011 9 26 http content 9 1 26 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Comparison of health-related quality of life measures in chronic obstructive pulmonary disease A Simon Pickard1 Yoojung Yang1 and Todd A Lee1 2 Abstract Background The aims of this study were 1 to compare the discriminative ability of a disease-specific instrument the St. George s Respiratory Questionnaire SGRQ to generic instruments . EQ-5D and SF-36 and 2 to evaluate the strength of associations among clinical and health-related quality of life HRQL measures in chronic obstructive pulmonary disease COPD . Methods We analyzed data collected from 120 COPD patients in a Veterans Affairs hospital. Patients selfcompleted two generic HRQL measures EQ-5D and SF-36 and the disease-specific SGRQ. The ability of the summary scores of these HRQL measures to discriminate COPD disease severity based on Global Obstructive Lung Disease GOLD stage was assessed using relative efficiency ratios REs . Strength of correlation was used to further evaluate associations between clinical and HRQL measures. Results Mean total scores for PCS-36 EQ-VAS and SGRQ were significantly lower for the more severe stages of COPD p . Using SGRQ total score as reference the summary scores of the generic measures PCS-36 MCS-36 EQ index and EQ-VAS all had REs of 1. SGRQ exhibited a stronger correlation with clinical measures than the generic summary scores. For instance SGRQ was moderately correlated with FEV1 r while generic summary scores had trivial levels of correlation with FEV1 r . Conclusions The SGRQ demonstrated greater ability to discriminate among different levels of severity stages of COPD than generic measures of health suggestive that SGRQ may provide COPD studies with greater statistical power than EQ-5D and SF-36 summary scores to capture meaningful differences in clinical severity. Keywords respiratory disease quality of