tailieunhanh - báo cáo hóa học:" Impact of osteoporosis and vertebral fractures on quality-of-life. a population-based study in Valencia, Spain (The FRAVO Study)"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Impact of osteoporosis and vertebral fractures on quality-of-life. a population-based study in Valencia, Spain (The FRAVO Study) | Sanfélix-Genovés et al. Health and Quality of Life Outcomes 2011 9 20 http content 9 1 20 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Impact of osteoporosis and vertebral fractures on quality-of-life. a population-based study in Valencia Spain The FRAVO Study José Sanfélix-Genovés1 2 Isabel Hurtado1 Gabriel Sanfelix-Gimeno1 Begona Reig-Molla3 and Salvador Peiró1 Abstract Background To describe the health related quality of life in a population sample of postmenopausal women over the age of 50 and resident in the city of Valencia Spain according to the presence absence of osteoporosis and the severity of prevalent morphometric vertebral fractures. Methods A cross-sectional age-stratified population-based sample of 804 postmenopausal women of 50 years of age and older were assessed with the SF-12 questionnaire. Information about demographic features lifestyle clinical features educational level anti-osteoporotic and other treatments comorbidities and risk factors for osteoporosis were collected using an interviewer-administered questionnaire and densitometric evaluation of spine and hip and spine x-rays were carried out. Results In the non-adjusted analysis mild and moderate-severe vertebral fractures were associated with decreased scores in the SF-12 Physical Component Summary PCS but not in the Mental Component Summary MCS while densitometric osteoporosis with no accompanying fracture was not associated with a worse health related quality of life. In multivariate analysis worse PCS scores were associated to the age groups over 70 for 70-74 group and for 75 and older chronic conditions and according to the presence of 1 2 or at least 3 conditions obesity peripheral fracture antecedents hypoestrogenism antecedents and the presence of vertebral fracture . Conclusions After adjusting for confounding factors the physical components of health related quality of life were significantly lower .