tailieunhanh - Báo cáo y học: " Dapsone-induced agranulocytosis leading to perianal abscess and death: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Dapsone-induced agranulocytosis leading to perianal abscess and death: a case report. | Kobe et al. Journal of Medical Case Reports 2011 5 107 http content 5 1 107 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Dapsone-induced agranulocytosis leading to perianal abscess and death a case report Yoshiro Kobe Daisuke Setoguchi Nobuya Kitamura Abstract Introduction Dapsone diaminodiphenylsulfone is used for the treatment of intractable skin diseases such as pemphigus and leprosy. The side effects of Dapsone are anemia leukopenia and liver dysfunction. Here we present a case of agranulocytosis-induced septic shock which was a side effect of Dapsone. Case presentation An 82-year-old Japanese woman was transferred to our hospital with fever leucopenia and respiratory arrest. At the previous hospital she had been administered Dapsone for linear IgA bullous dermatosis. At the time of admission she presented with methemoglobinemia and septic shock which was due to immunosuppression caused by the normal dose of Dapsone. Although her overall health initially improved her condition deteriorated because of septic shock caused by an anal fistula. She died of sepsis on hospital day 80. Conclusion One of the side effects of Dapsone is agranulocytosis. Patients with agranulocytosis may be in danger of developing anal fistula. Therefore care must be taken if a patient with agranulocytosis develops a decubitus ulcer in the sacral region since it could develop into a fistula-in-ano. Introduction Dapsone diaminodiphenylsulfone has been used for treating intractable skin diseases such as leprosy and dermatitis herpetiformis. The side effects associated with the use of Dapsone inclu de hemolytic anemia methemoglobinemia and agranulocytosis 1 . Agranulocytosis is a rare condition however it can become a life-threatening illness if sepsis develops. We report a case of agranulocytosis as a side effect of Dapsone which was administered to a patient for treating linear IgA bullous dermatosis LABD . Agranulocytosis-induced septic shock and .