tailieunhanh - Báo cáo y học: " Parkinsonism caused by adverse drug reactions: a case series."

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Parkinsonism caused by adverse drug reactions: a case series. | Ugoya et al. Journal of Medical Case Reports 2011 5 105 http content 5 1 105 JOURNALOF medical case reports CASE REPORT Open Access Parkinsonism caused by adverse drug reactions a case series Solomon O Ugoya Emmanuel I Agaba Comfort A Daniyam Abstract Introduction Parkinsonism puts a high direct cost burden on both patient and caregiver. Several reports of drug-induced parkinsonism have been published but to the best of our knowledge there has not been any report of quinine or halothane inducing parkinsonism. Case presentation We describe two cases of parkinsonism possibly caused by adverse drug reaction to quinine in a 29-year-old black Nigerian woman and to halothane in a 36-year-old black Hausa Nigerian man who received it as general anaesthesia for appendicectomy in our teaching hospital. Conclusion These are two unusual cases of parkinsonism caused by adverse drug reactions to high-dose quinine and to halothane as general anaesthesia. We consider that these two cases are important in bringing this potential side-effect to the attention of both pharmacologists and primary care physicians as these are two of the most commonly used medications in our clinics. We conclude that parkinsonism should be included among the adverse drug reactions to high-dose quinine and halothane general anaesthetic. Introduction The most common cause of parkinsonism is Parkinson s Disease PD accounting for approximately of cases followed by parkinsonism-plus syndrome . Secondary causes such as drugs trauma vascular conditions acquired immunodeficiency disease and toxins make up around and the remaining of cases are classified as Heredodegenerative parkinsonism 1 . Quinine was the first antimalarial drug available which has been in use since the 17th century 2 . Quinine is a natural white crystalline alkaloid with antipyretic effects. It is a stereoisomer of quinidine which has an antiar-rhythmic effect. Side effects of quinine include .