tailieunhanh - Báo cáo y học: "Proximal myopathy in lacto-vegetarian Asian patients responding to Vitamin D and calcium supplement therapy - two case reports and review of the literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Proximal myopathy in lacto-vegetarian Asian patients responding to Vitamin D and calcium supplement therapy - two case reports and review of the literature. | Thabit et al. Journal of Medical Case Reports 2011 5 178 http content 5 1 178 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Proximal myopathy in lacto-vegetarian Asian patients responding to Vitamin D and calcium supplement therapy - two case reports and review of the literature Hood Thabit 1 Maurice Barry2 Seamus Sreenan3 and Diarmuid Smith1 Abstract Introduction Severe proximal myopathy can occasionally be the first presenting complaint of patients with osteomalacia. This may lead to investigations and misdiagnosis of a neuromuscular disease rather than a metabolic bone disease. Case presentations We present here two cases of severe proximal myopathy in patients who were both of South Asian origin and lacto-vegetarians a 31-year-old Indian man and a 34-year-old Indian woman. In both cases their clinical symptoms fully resolved following vitamin D and calcium replacement therapy. These patients were at risk of osteomalacia due to their dietary intake and ethnicity. The role of dietary intake and sunlight exposure in the development of osteomalacia in certain ethnic groups living in Western Europe is reviewed here. Conclusion These two cases emphasize the importance of recognizing osteomalacia in at-risk individuals as the condition is reversible and easily treated with vitamin D and calcium supplementation. It may also help avoid prolonged and unnecessary investigations of these patients. Introduction Osteomalacia can present for the first time in some patients as severe muscle weakness and difficulty walking. Proximal myopathy can be present in up to 13 of patients with osteomalacia 1 . This may lead to investigations and misdiagnosis of neuromuscular disease rather than a metabolic bone disease. It is therefore important in patients known to be at risk of vitamin D deficiency to consider a diagnosis of osteomalacia as it is easily treatable and reversible. We present here two cases of vitamin D deficiency-induced myopathy. .