tailieunhanh - Báo cáo y học: " Multifocal invasive ductal breast cancer with osteoclast-like giant cells: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Multifocal invasive ductal breast cancer with osteoclast-like giant cells: a case report. | Richter et al. Journal of Medical Case Reports 2011 5 85 http content 5 1 85 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Multifocal invasive ductal breast cancer with osteoclast-like giant cells a case report Georg Richter1 Christoph Uleer2 Thomas Noesselt3 Abstract Introduction To the best of our knowledge this is the first case report of a multifocal trifocal invasive carcinoma of the breast containing osteoclast-like giant cells. Case presentation A 64-year-old Caucasian woman presented for routine mammography screening with three radiodense lesions in the lower inner quadrant of the right breast a primary breast cancer. Microscopic examination showed three foci of invasive ductal carcinoma with multinucleated osteoclast-like giant cells. Osteoclast-like giant cells in breast cancer are a rare phenomenon. They are described in less than two percent of all breast cancers and occur in association with invasive ductal cancer and invasive lobular cancer. In addition osteoclast-like giant cells have been described in several sarcomas and metaplastic carcinomas of the breast. Conclusion To the best of our knowledge this is the first report of a multifocal infiltrating ductal carcinoma of the breast containing osteoclast-like giant cells. This could be an indication for a possible early event in carcinogenesis associated with a biological event or secretion that indicates the differentiation and or migration of stromal cells or macrophages. Introduction Carcinoma of the breast containing osteoclast-like giant cells is uncommon and described in less than 2 of breast cancer patients 1-3 . In addition osteoclast-like giant cells are described in a ductal carcinoma in situ and metaplastic carcinomas of the breast 4 5 although the stromal origin of the giant cells is unknown. Immunohistochemical and ultrastructural studies suggest that the osteoclast-like giant cells are of stromal histiocytic origin or might be differentiated from .