tailieunhanh - Báo cáo y học: " Paediatric Behçet’s disease presenting with recurrent papillitis and episcleritis: a case repor"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Paediatric Behçet’s disease presenting with recurrent papillitis and episcleritis: a case report. | Parentin et al. Journal of Medical Case Reports 2011 5 81 http content 5 1 81 JOURNALOF medical case reports CASE REPORT Open Access Paediatric Behcet s disease presenting with recurrent papillitis and episcleritis a case report Fulvio Parentin1 Loredana Lepore2 Ingrid Rabach2 Stefano Pensiero1 Abstract Introduction Behget s disease is a chronic multisystem vasculitis characterized by mucocutaneous articular neurological gastrointestinal and ophthalmological lesions. Ocular involvement is mainly represented by recurrent uveitis especially posterior uveitis however iridocyclitis retinal and choroidal vasculitis optic neuritis and retinal vascular occlusion can also occur. Case presentation A 12-year-old Caucasian boy with a history of recurrent buccal aphthosis and nonspecific gastrointestinal symptoms was admitted to our hospital with blurred vision associated with acute episcleritis and papillitis. The patient s pathergy test was positive suggesting a diagnosis of Behget s disease. Corticosteroid and cyclosporine therapy was started but further episodes were noted in both eyes. The patient was then switched to intravenous infliximab with complete resolution of the inflammation after the second infusion. Conclusion Episcleritis and papillitis should be added to the list of uncommon manifestations of pediatric Behget s disease. Infliximab is an effective new therapeutic approach for Behget s disease that is refractory to the conventional corticosteroid and immunosuppressive therapy. Introduction Behcet s disease is a chronic multisystem vasculitis characterized by mucocutaneous articular neurological gastrointestinal and ophthalmological lesions 1 . The hallmark of ocular involvement is recurrent uveitis especially posterior uveitis however iridocyclitis retinal and choroidal vasculitis optic neuritis and retinal vascular occlusion can also occur 2 . Other ocular manifestations such as scleritis are very unusual and are described only .