tailieunhanh - Báo cáo y học: "Plasmablastic lymphoma in the ano-rectal junction presenting in an immunocompetent man: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Plasmablastic lymphoma in the ano-rectal junction presenting in an immunocompetent man: a case report. | Brahmania et al. Journal of Medical Case Reports 2011 5 168 http content 5 1 168 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Plasmablastic lymphoma in the ano-rectal junction presenting in an immunocompetent man a case report Mayur Brahmania Thomas Sylwesterowic and Heather Leitch Abstract Introduction Plasmablastic lymphoma is an aggressive non-Hodgkin lymphoma classically occurring in individuals infected with HIV. Plasmablastic lymphoma has a predilection for the oral cavity and jaw. However recent case reports have shown lymphoma in the stomach lung nasal cavity cervical lymph nodes and jejunum in HIVnegative individuals. We report what is to the best of our knowledge the first case of plasmablastic lymphoma occurring in the ano-rectal junction of an HIV-negative man. Case Presentation A previously healthy 59-year-old Caucasian man presented with painless rectal bleeding. Colonoscopy revealed a lesion in the ano-rectal junction with pathological examination demonstrating atypical lymphoid cells consisting primarily of plasmablasts with rounded nuclei coarse chromatin small nucleoli and multiple mitotic figures. Immunohistochemical analysis showed the atypical cells were negative for CD45 CD20 CD79a and immunoglobulin light chains but were strongly positive for CD138 and EBV-encoded RNA. The results were consistent with a diagnosis of plasmablastic lymphoma. Aggressive systemic chemotherapy and involved field radiation therapy resulted in complete clinical and pathological remission. Conclusion Increasing awareness of plasmablastic lymphoma in HIV-negative individuals and in this location is warranted. Introduction Plasmablastic lymphoma PBL is most frequently an AIDS-related non-Hodgkin lymphoma NHL and is usually confined to the oral cavity and jaws although involvement of distant sites may occur 1-6 . It is a rapidly progressive tumor usually seen in human immunodeficiency virus HIV infection with advanced .