tailieunhanh - báo cáo khoa học: "Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system | Xie and Smith Journal of Nanobiotechnology 2010 8 18 http content 8 1 18 JOURNAL OF NANOBIOTECHNOLOGY RESEARCH Open Access Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system Hui Xie Jeffrey W Smith Abstract Particle size is a key feature in determining performance of nanoparticles as drug carriers because it influences circulating half-life cellular uptake and biodistribution. Because the size of particles has such a major impact on their performance the uniformity of the particle population is also a significant factor. Particles comprised of the polymer poly lactic-co-glycolic acid PLGA are widely studied as therapeutic delivery vehicles because they are biodegradable and biocompatible. In fact microparticles comprised of PLGA are already approved for drug delivery. Unfortunately PLGA nanoparticles prepared by conventional methods usually lack uniformity. We developed a novel Fluidic NanoPrecipitation System FNPS to fabricate highly uniform PLGA particles. Several parameters can be fine-tuned to generate particles of various sizes. Background Particles comprised of the polymer poly lactic-co-glyco-lic acid PLGA are widely studied as therapeutic delivery vehicles because they are biodegradable 1 and biocompatible 2-4 . In fact microparticles comprised of PLGA are already approved for establishing sustained release of leuprolide Lupron Depot and triptorelin Trelstar . Similar PLGA particles also show promise as a delivery vehicle for proteins 5 6 siRNA 7 and for presenting antigens to dendritic cells for vaccination 8-10 . It is also becoming clear that PLGA particles offer considerable flexibility in choosing a route of delivery because they have proven to be effective when injected intramuscularly 11 12 when delivered via inhalation 13-15 and recent results indicate that they also have promise for oral delivery of drugs and antigens 16-19 . Particle size is one of the key features in determining performance .