tailieunhanh - Báo cáo y học: "Methicillin sensitive Staphylococcus aureus producing Panton-Valentine leukocidin toxin in Trinidad & Tobago: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Methicillin sensitive Staphylococcus aureus producing Panton-Valentine leukocidin toxin in Trinidad & Tobago: a case report. | Akpaka et al. Journal of Medical Case Reports 2011 5 157 http content 5 1 157 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Methicillin sensitive Staphylococcus aureus producing Panton-Valentine leukocidin toxin in Trinidad Tobago a case report 1 2 4 Patrick E Akpaka Stefan Monecke William H Swanston 1 AV Chalapathi Rao 1 Renee Schulz and Paul N Levett4 Abstract Introduction Certain Staphylococcus aureus strains produce Panton-Valentine leukocidin a toxin that lyses white blood cells causing extensive tissue necrosis and chronic recurrent or severe infection. This report documents a confirmed case of methicillin-sensitive Staphylococcus aureus strain harboring Panton-Valentine leukocidin genes from Trinidad and Tobago. To the best of our knowledge this is the first time that such a case has been identified and reported from this country. Case presentation A 13-year-old Trinidadian boy of African descent presented with upper respiratory symptoms and gastroenteritis-like syptoms. About two weeks later he was re-admitted to our hospital complaining of pain and weakness affecting his left leg where he had received an intramuscular injection of an anti-emetic drug. He deteriorated and developed septic arthritis necrotizing fasciitis and septic shock with acute respiratory distress syndrome leading to death within 48 hours of admission despite intensive care treatment. The infection was caused by S. aureus. Bacterial isolates from specimens recovered from our patient before and after his death were analyzed using microarray DNA analysis and spa typing and the results revealed that the S. aureus isolates belonged to clonal complex 8 were methicillin-susceptible and positive for Panton-Valentine leukocidin. An autopsy revealed multi-organ failure and histological tissue stains of several organs were also performed and showed involvement of his lungs liver kidneys and thymus which showed Hassal s corpuscles. Conclusion Rapid .