tailieunhanh - báo cáo khoa học: "Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice | BarathManiKanth et al. Journal of Nanobiotechnology 2010 8 16 http content 8 1 16 RESEARCH JOURNAL OF NANOBIOTECHNOLOGY Open Access Anlti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice Selvaraj BarathManiKanth21 Kalimuthu Kalishwaralal21 Muthuirulappan Sriram 1 SureshBabu Ram Kumar Pandian1 Hyung-seop Youn2 SooHyun Eom2 and Sangiliyandi Gurunathan 1 Abstract Background Oxidative stress is imperative for its morbidity towards diabetic complications where abnormal metabolic milieu as a result of hyperglycemia leads to the onset of several complications. A biological antioxidant capable of inhibiting oxidative stress mediated diabetic progressions during hyperglycemia is still the need of the era. The current study was performed to study the effect of biologically synthesized gold nanoparticles AuNPs to control the hyperglycemic conditions in streptozotocin induced diabetic mice. Results The profound control of AuNPs over the anti oxidant enzymes such as GSH SOD Catalase and GPx in diabetic mice to normal by inhibition of lipid peroxidation and ROS generation during hyperglycemia evidence their antioxidant effect during hyperglycemia. The AuNPs exhibited an insistent control over the blood glucose level lipids and serum biochemical profiles in diabetic mice near to the control mice provokes their effective role in controlling and increasing the organ functions for better utilization of blood glucose. Histopathological and hematological studies revealed the non-toxic and protective effect of the gold nanoparticles over the vital organs when administered at dosage of mg day. ICP-MS analysis revealed the biodistribution of gold nanoparticles in the vital organs showing accumulation of AuNPs in the spleen comparatively greater than other organs. Conclusion The results obtained disclose the effectual role of AuNPs as an anti-oxidative agent by inhibiting the formation of ROS .