tailieunhanh - báo cáo khoa học: "Naturally occurring nanoparticles from English ivy: an alternative to metal-based nanoparticles for UV protection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Naturally occurring nanoparticles from English ivy: an alternative to metal-based nanoparticles for UV protection | Xia et al. Journal of Nanobiotechnology 2010 8 12 http content 8 1 12 RESEARCH JOURNAL OF NANOBIOTECHNOLOGY Open Access Naturally occurring nanoparticles from English ivy an alternative to metal-based nanoparticles for UV protection Lijin Xia Scott C Lenaghan 1 Mingjun Zhang Zhili Zhang and Quanshui Li Abstract Background Over the last decade safety concerns have arisen about the use of metal-based nanoparticles in the cosmetics field. Metal-based nanoparticles have been linked to both environmental and animal toxicity in a variety of studies. Perhaps the greatest concern involves the large amounts of TiO2 nanoparticles that are used in commercial sunscreens. As an alternative to using these potentially hazardous metal-based nanoparticles we have isolated organic nanoparticles from English ivy Hederahelix . In this study ivy nanoparticles were evaluated for their potential use in sunscreens based on four criteria 1 ability to absorb and scatter ultraviolet light 2 toxicity to mammalian cells 3 biodegradability and 4 potential for diffusion through skin. Results Purified ivy nanoparticles were first tested for their UV protective effects using a standard spectrophotometric assay. Next the cell toxicity of the ivy nanoparticles was compared to TiO2 nanoparticles using HeLa cells. The biodegradability of these nanoparticles was also determined through several digestion techniques. Finally a mathematical model was developed to determine the potential for ivy nanoparticles to penetrate through human skin. The results indicated that the ivy nanoparticles were more efficient in blocking UV light less toxic to mammalian cells easily biodegradable and had a limited potential to penetrate through human skin. When compared to TiO2 nanoparticles the ivy nanoparticles showed decreased cell toxicity and were easily degradable indicating that they provided a safer alternative to these nanoparticles. Conclusions With the data collected from this study we