tailieunhanh - báo cáo khoa học: "Biotechnology approach to determination of genetic and epigenetic control in cells"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Biotechnology approach to determination of genetic and epigenetic control in cells | Journal of Nanobiotechnology BioMed Central Review Open Access Biotechnology approach to determination of genetic and epigenetic control in cells Kenji Yasuda Address Department of Life Sciences Graduate school of Arts and Sciences University of Tokyo 3-8-1 Komaba Meguro Tokyo 153-8902 JAPAN Email Kenji Yasuda - cyasuda@ Corresponding author Published 22 November 2004 Received 21 December 2003 Accepted 22 November 2004 Journal of Nanobiotechnology 2004 2 11 doi l477-3l55-2- II This article is available from http content 2 l ll 2004 Yasuda licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A series of studies aimed at developing methods and systems for analyzing epigenetic information in cells are presented. The role of the epigenetic information of cells which is complementary to their genetic information was inferred by comparing the predictions of genetic information with the cell behaviour observed under conditions chosen to reveal adaptation processes and community effects. Analysis of epigenetic information was developed starting from the twin complementary viewpoints of cells regulation as an algebraic system emphasis on the temporal aspect and as a geometric system emphasis on the spatial aspect . The knowlege acquired from this study will lead to the use of cells for fully controlled practical applications like cell-based drug screening and the regeneration of organs. Review I. General background Knowledge about living organisms increased dramatically during the 20th century and has produced the modern disciplines of genomics and proteomics. Despite these advances however there remains the great challenge of learning how the different living components .