tailieunhanh - báo cáo khoa học: " Modification of a neuronal network direction using stepwise photo-thermal etching of an agarose architecture"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Modification of a neuronal network direction using stepwise photo-thermal etching of an agarose architecture | Journal of Nanobiotechnology BioMed Central Research Open Access Modification of a neuronal network direction using stepwise photo-thermal etching of an agarose architecture Ikurou Suzuki1 Yoshihiro Sugio1 Hiroyuki Moriguchi1 Yasuhiko Jimbo2 and Kenji Yasuda 1 Address Department of Life Sciences Graduate school of Arts and Sciences University of Tokyo 3-8-1 Komaba Meguro Tokyo 153-8902 JAPAN and 2Department of Precision Engineering Graduate School of Engineering University of Tokyo 7-3-1 Hongou Bunkyo Tokyo 113-0033 JAPAN Email Ikurou Suzuki - ikurou@ Yoshihiro Sugio - sugio_yoshihiro@ Hiroyuki Moriguchi - moriguchi_hiroyuki@ Yasuhiko Jimbo - jimbo@ Kenji Yasuda - cyasuda@ Corresponding author Published 01 July 2004 Received 11 December 2003 Journal of Nanobiotechnology 2004 2 7 doi 1477-3155-2-7 Accepted 01 July 2004 This article is available from http content 2 1 7 2004 Suzuki et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Control over spatial distribution of individual neurons and the pattern of neural network provides an important tool for studying information processing pathways during neural network formation. Moreover the knowledge of the direction of synaptic connections between cells in each neural network can provide detailed information on the relationship between the forward and feedback signaling. We have developed a method for topographical control of the direction of synaptic connections within a living neuronal network using a new type of individual-cell-based on-chip cellcultivation system with an agarose microchamber array AMCA . The advantages of this system include the possibility to control positions and number of .