tailieunhanh - báo cáo hóa học:" Comparison between the disease-specific Airways Questionnaire 20 and the generic 15D instruments in COPD"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Comparison between the disease-specific Airways Questionnaire 20 and the generic 15D instruments in COPD | Mazur et al. Health and Quality of Life Outcomes 2011 9 4 http content 9 1 4 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Comparison between the disease-specific Airways Questionnaire 20 and the generic 15D instruments in COPD 1 1 2 3 2 1 Witold Mazur Henna Kupiainen Janne Pitkaniemi Maritta Kilpelainen Harri Sintonen Ari Lindqvist Vuokko L Kinnula1 Tarja Laitinen4 Abstract Background Given that the assessment of health-related quality of life HRQoL is an essential outcome measure to optimize chronic obstructive pulmonary disease COPD patient management there is a need for a short and fast reliable and valid instrument for routine use in clinical practice. The objective of this study was to analyse the relationship between the disease-specific Airways questionnaire AQ20 and the generic 15D health-related quality of life HRQoL instrument simultaneously in a large cohort of patients with COPD. We also compare the HRQoL of COPD patients with that of the general population. Methods The AQ20 and 15D were administered to 739 COPD patients representing an unselected hospital-based COPD population. The completion rates and validity of and correlations among the questions and dimension scores were examined. A factor analysis with varimax rotation was performed in order to find subsets of highly correlating items of the questionnaires. Results The summary scores of AQ20 and 15D were highly correlated r - p . In AQ20 over 50 of patients reported frequent cough breathlessness during domestic work and chest problem limiting their full enjoyment of life. 15D results showed a noteworthy decrease of HRQoL in breathing mobility sleeping usual activities discomfort and symptoms vitality and sexual activity scores . Compared to the age- and gender-standardized Finnish general population the COPD patients were statistically significantly worse off on 13 of 15 dimensions. Conclusions The AQ20 and 15D summary scores are comparable in terms of .