tailieunhanh - báo cáo khoa học: " Quantum dots improve peptide detection in MALDI MS in a size dependent manner"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Quantum dots improve peptide detection in MALDI MS in a size dependent manner | Journal of Nanobiotechnology BioMed Central Research Quantum dots improve peptide detection in MALDI MS in a size dependent manner Julian Bailes1 Loic Vidal2 Dimitri A Ivanov2 and Mikhail Soloviev 1 Address 1School of Biological Sciences Royal Holloway University of London Egham Surrey TW20 0EX UK and 2IS2M CNRS LRC7228 15 rue Jean Starcky 68057 Mulhouse France Email Julian Bailes - Loic Vidal - Dimitri A Mikhail Soloviev - Corresponding author Open Access Published 31 December 2009 Received 21 December 2005 r. - n J . rr Accepted 31 December 2009 Journal of Nanobiotechnology 2009 7 10 doi I86 I477-3I55-7-I0 This article is available from http content 7 1 10 2009 Bailes et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Laser Desorption Ionization Mass Spectrometry employs matrix which is co-crystallised with the analyte to achieve soft ionization that is the formation of ions without fragmentation. A variety of matrix-free and matrix-assisted LDI techniques and matrices have been reported to date. LDI has been achieved using ultra fine metal powders UFMPs desorption ionisation on silicon DIOS sol-gel assisted laser desorption ionization SGALDI as well as with common MALDI matrices such as 2 5-dihydroxy benzoic acid DHB 3 5-dimethoxy-4-hydroxycinnamic acid SA a-cyano-4-hydroxycinnamic acid CHCA to name a few. A variety of matrix additives have been shown to improve matrix assisted desorption including silicon nanowires SiNW carbon nanotubes CNT metal nanoparticles and nanodots. To our knowledge no evidence exists for the application of highly fluorescent CdSe ZnS quantum dots to .