tailieunhanh - báo cáo khoa học: " Real time in vitro studies of doxorubicin release from PHEMA nanoparticles"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Real time in vitro studies of doxorubicin release from PHEMA nanoparticles | Journal of Nanobiotechnology BioMed Central Research Real time in vitro studies of doxorubicin release from PHEMA nanoparticles Raje Chouhan and AK Bajpai Address Bose Memorial Research Laboratory Department of Chemistry Government Autonomous Science College Jabalpur MP -482001 India Email Raje Chouhan - raje2183@ AK Bajpai - akbmrl@ Corresponding author Open Access Published 20 October 2009 Received 10 July 2009 r J. rr r Accepted 20 October 2009 Journal of Nanobiotechnology 2009 7 5 doi 1477-3155-7-5 This article is available from http content 7 1 5 2009 Chouhan and Bajpai licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Many anticancer agents have poor water solubility and therefore the development of novel delivery systems for such molecules has received significant attention. Nanocarriers show great potential in delivering therapeutic agents into the targeted organs or cells and have recently emerged as a promising approach to cancer treatments. The aim of this study was to prepare and use poly-2-hydroxyethyl methacrylate PHEMA nanoparticles for the controlled release of the anticancer drug doxorubicin. Results PHEMA nanoparticles have been synthesized and characterized using FTIR and scanning electron microscopy SEM particle size analysis and surface charge measurements. We also studied the effects of various parameters such as percent loading of drugs chemical architecture of the nanocarriers pH temperature and nature of the release media on the release profiles of the drug. The chemical stability of doxorubicin in PBS was assessed at a range of pH. Conclusion Suspension polymerization of 2-hydroxyethyl methacrylate HEMA results in the .

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