tailieunhanh - báo cáo khoa học: "Toxicity of CdSe Nanoparticles in Caco-2 Cell Cultures"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Toxicity of CdSe Nanoparticles in Caco-2 Cell Cultures | Journal of Nanobiotechnology BioMed Central Research Toxicity of CdSe Nanoparticles in Caco-2 Cell Cultures Lin Wang1 Dattatri K Nagesha2 Selvapraba Selvarasah3 Mehmet R Dokmeci3 and Rebecca L Carrier 1 Open Access Address 1Chemical Engineering Department Northeastern University Boston MA 02115 USA 2Physics Department Northeastern University Boston MA 02115 USA and 3Electrical and Computer Engineering Department Northeastern University Boston MA 02115 USA Email Lin Wang - Dattatri K Nagesha - Selvapraba Selvarasah - Mehmet R Dokmeci - mehmetd@ Rebecca L Carrier - Corresponding author Published 23 October 2008 Received 16 March 2008 . J . n rr Accepted 23 October 2008 Journal of Nanobiotechnology 2008 6 11 doi l477-3l55-6-l I This article is available from http content 6 l ll 2008 Wang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Potential routes of nanomaterial exposure include inhalation dermal contact and ingestion. Toxicology of inhalation of ultra-fine particles has been extensively studied however risks of nanomaterial exposure via ingestion are currently almost unknown. Using enterocyte-like Caco-2 cells as a small intestine epithelial model the possible toxicity of CdSe quantum dot QD exposure via ingestion was investigated. Effect of simulated gastric fluid treatment on CdSe QD cytotoxicity was also studied. Results Commercially available CdSe QDs which have a ZnS shell and poly-ethylene glycol PEG coating and in-house prepared surfactant coated CdSe QDs were dosed to Caco-2 cells. Cell viability and attachment were studied after 24 hours of incubation. It was found .