tailieunhanh - báo cáo khoa học: "A micro-fluidic study of whole blood behaviour on PMMA topographical nanostructures"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A micro-fluidic study of whole blood behaviour on PMMA topographical nanostructures | Journal of Nanobiotechnology BioMed Central Research A micro-fluidic study of whole blood behaviour on PMMA topographical nanostructures Caterina Minelli 1 2 Akemi Kikuta3 Nataliya Tsud4 Michael D Ball2 and Akiko Yamamoto3 Open Access Address 1International Centre for Young Scientists National Institute for Materials Science 1-1 Namiki Tsukuba Ibaraki 305-0044 Japan 2Department of Materials Imperial College London Exhibition road SW7 2AZ London UK 3Biomaterial Centre National Institute for Materials Science 1-1 Namiki Tsukuba Ibaraki 305-0044 Japan and 4Nanomaterials Laboratory National Institute for Materials Science 1-1 Namiki Tsukuba Ibaraki 305-0044 Japan Email Caterina Minelli - Akemi Kikuta - Nataliya Tsud - Michael D Ball - Corresponding author Published 19 February 2008 Received 12 September 2007 Accepted 19 February 2008 Journal of Nanobiotechnology 2008 6 3 doi l477-3l55-6-3 This article is available from http content 6 l 3 2008 Minelli et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Polymers are attractive materials for both biomedical engineering and cardiovascular applications. Although nano-topography has been found to influence cell behaviour no established method exists to understand and evaluate the effects of nano-topography on polymer-blood interaction. Results We optimized a micro-fluidic set-up to study the interaction of whole blood with nanostructured polymer surfaces under flow conditions. Micro-fluidic chips were coated with polymethylmethacrylate films and structured by polymer demixing. Surface feature .