tailieunhanh - báo cáo khoa học: " Internalization of ferromagnetic nanowires by different living cells"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Internalization of ferromagnetic nanowires by different living cells | Journal of Nanobiotechnology BioMed Central Research Internalization of ferromagnetic nanowires by different living cells Adriele Prina-Mello Zhu Diao and John Michael David Coey Open Access Address Centre for Research on Adaptive Nanostructures and Nanodevices CRANN and School of Physics. Trinity College Dublin Dublin 2 Ireland Email Adriele Prina-Mello - prinamea@ Zhu Diao - diaoz@ John Michael David Coey- jcoey@ Corresponding author Published 05 September 2006 Received 21 June 2006 . rr . Accepted 05 September 2006 Journal of Nanobiotechnology 2006 4 9 doi l477-3l55-4-9 This article is available from http content 4 l 9 2006 Prina-Mello et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ The ability of living cells either adherent or suspended to internalize nickel nanowires is demonstrated for MC3T3-E1 UMRl 06-tumour and Marrow-Stromal cells. Nanowires were produced by electrodeposition 20 pm long and 200 nm in diameter. Cell separation and manipulation was achieved for the three cell types. Applied magnetic field successfully oriented the internalized nanowires but no clear anisotropy is induced on the adherent cells. Nanowires tend to bind to cytoplasm metalloproteins and trigger lysosome reorganization around the nucleus. This work demonstrates the applications of nanowires in adherent and suspended cells for cell separation and manipulation and further explore into their role in nanobiotechnology. Background Ferromagnetic nanoparticles have found widespread uses in modern biology and medicine 1-3 . They are used as contrast agents for magnetic resonance imaging 4 localized .