tailieunhanh - Health and Quality of Life Outcomes BioMed Central Research Open Access Validation of a

Health and Quality of Life Outcomes BioMed Central Research Open Access Validation of a patient-administered questionnaire to measure the activity impairment experienced by women with uncomplicated urinary tract infection: the Activity Impairment Assessment (AIA) Diane J Wild*1, Darren J Clayson1, Karen Keating2 and Kathleen Gondek2 Address: 1Oxford Outcomes Ltd, Old Barn, Jericho Farm, Cassington, Oxford, OX29 4SZ, UK and 2Bayer Healthcare Pharmaceuticals, 400 Morgan Lane, West Haven, CT 06515-4175, USA Email: Diane J Wild* - ; Darren J Clayson - ; Karen Keating - ; Kathleen Gondek - * Corresponding author Published: 15 July 2005 Health and Quality of Life Outcomes 2005, 3:42 42 doi: Received: 23. | Health and Quality of Life Outcomes BioMed Central Research Open Access Validation of a patient-administered questionnaire to measure the activity impairment experienced by women with uncomplicated urinary tract infection the Activity Impairment Assessment AIA Diane J Wild 1 Darren J Clayson1 Karen Keating2 and Kathleen Gondek2 Address 1Oxford Outcomes Ltd Old Barn Jericho Farm Cassington Oxford OX29 4SZ UK and 2Bayer Healthcare Pharmaceuticals 400 Morgan Lane West Haven CT 06515-4175 USA Email Diane J Wild - Darren J Clayson - Karen Keating - Kathleen Gondek - Corresponding author Published 15 July 2005 Received 23 March 2005 Health and Quality ofLife Outcomes 2005 3 42 doi 1477-7525-3- Accepted 15 July 2005 42 This article is available from http content 3 1 42 2005 Wild et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background To validate a questionnaire to assess the activity impairment associated with uncomplicated urinary tract infection uUTI . Methods The Activity Impairment Assessment AIA assesses the amount of time an individual s work or regular activities have been impaired as a result of their UTI. The measure was completed by 276 women with uUTI who had participated in a prospective open-label non-comparative multi-centre clinical trial of CIPRO XR extended-release ciprofloxacin . Baseline scores on the King s Health Questionnaire KHQ and clinical symptom evaluations were collected for validation purposes. Results An exploratory factor analysis showed that all items loaded on a single component. This uni-dimensional structure was supported by Rasch .

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