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Health and Quality of Life Outcomes BioMed Central Review Open Access Health-related quality of life measurement in pediatric clinical practice: An appraisal and precept for future research and application James W Varni*1, Tasha M Burwinkle2 and Mariella M Lane3 Address: 1Department of Pediatrics, College of Medicine, Department of Landscape Architecture and Urban Planning, College of Architecture, Texas A&M University, 3137 TAMU, College Station, TX 77843-3137 USA, 2Department of Anesthesiology, University of Washington, 1945 NE Pacific Street, Seattle, WA 98195 USA and 3Department of Psychology, College of Liberal Arts, Texas A&M University, College Station, TX 77843 USA Email: James W Varni* - jvarni@; Tasha M Burwinkle -. | BioMed Central Health and Quality of Life Outcomes Review Open Access Health-related quality of life measurement in pediatric clinical practice An appraisal and precept for future research and application James WVarni 1 Tasha M Burwinkle2 and Mariella M Lane3 Address Department of Pediatrics College of Medicine Department of Landscape Architecture and Urban Planning College of Architecture Texas A M University 3137 TAMU College Station TX 77843-3137 USA 2Department of Anesthesiology University of Washington 1945 NE Pacific Street Seattle WA 98195 USA and 3Department of Psychology College of Liberal Arts Texas A M University College Station TX 77843 USA Email James WVarni - jvarni@ Tasha M Burwinkle - tmburwinkle@ Mariella M Lane - mariella@ Corresponding author Published 16 May 2005 Received 05 May 2005 Health and Quality ofLife Outcomes 2005 3 34 doi l477-7525-3-34 Accepted 16 May 2005 This article is available from http content 3 1 34 2005 Varni et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Health-related quality of life HRQOL measurement has emerged as an important health outcome in clinical trials clinical practice improvement strategies and healthcare services research and evaluation. HRQOL measures are also increasingly proposed for use in clinical practice settings to inform treatment decisions. In settings where HRQOL measures have been utilized with adults physicians report such measures as useful some physicians alter their treatment based on patient reports on such instruments and patients themselves generally feel the instruments to be helpful. However there is a dearth of studies evaluating the clinical utility of HRQOL measurement in .