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Health and Quality of Life Outcomes BioMed Central Research Open Access Health-related quality of life deficits associated with varying degrees of disease severity in type 2 diabetes Sheri L Maddigan1,2, Sumit R Majumdar1,3, Ellen L Toth1,4, David H Feeny1,2,5,6, Jeffrey A Johnson*1,2 and the DOVE Investigators1 Address: 1Institute of Health Economics, Edmonton, AB, CANADA, 2Department of Public Health Sciences, University of Alberta, Edmonton, AB, CANADA, 3Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, AB, CANADA, 4Division of Endocrinology & Metabolism; University of Alberta, Edmonton, AB, CANADA, 5Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, CANADA and 6Health Utilities Inc,. | BioMed Central Health and Quality of Life Outcomes Research Open Access Health-related quality of life deficits associated with varying degrees of disease severity in type 2 diabetes Sheri L Maddigan1 2 Sumit R Majumdar1 3 Ellen L Toth1 4 David H Feeny1 2 5 6 Jeffrey A Johnson 1 2 and the DOVE Investigators1 Address 1Institute of Health Economics Edmonton AB CANADA 2Department of Public Health Sciences University of Alberta Edmonton AB CANADA 3Division of General Internal Medicine Department of Medicine University of Alberta Edmonton AB CANADA 4Division of Endocrinology Metabolism University of Alberta Edmonton AB CANADA 5Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB CANADA and 6Health Utilities Inc Dundas ON CANADA Email Sheri L Maddigan - maddigan@ Sumit R Majumdar - Ellen LToth - David H Feeny - dfeeny@ Jeffrey A Johnson - jeffjohnson@ the DOVE Investigators - Corresponding author Published 15 December 2003 Received 03 November 2003 Accepted 15 December 2003 Health and Quality of Life Outcomes 2003 1 78 r This article is available from http content l l 78 2003 Maddigan et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background Diabetes is a chronic medical condition accompanied by a considerable health-related quality of life HRQL burden. The purpose of this analysis was to use generic measures of HRQL to describe HRQL deficits associated with varying degrees of severity of type 2 diabetes. Methods The RAND-l2 physical and mental health composites PHC and MHC respectively and Health Utilities Index Mark 3 HUI3 were self-completed by 372 subjects enrolled in a prospective controlled study of an intervention to improve care for .