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Health and Quality of Life Outcomes BioMed Central Research Open Access Health-related quality of life improves with treatment-related GERD symptom resolution after adjusting for baseline severity Dennis A Revicki*1, Marc W Zodet2, Sandra Joshua-Gotlib3, Douglas Levine3 and Joseph A Crawley3 Address: 1Center for Health Outcomes Research, MEDTAP International, Inc., Bethesda, Maryland, USA, 2Agency for Health Research and Quality, Rockville, Maryland, USA and 3AstraZeneca LP, Wayne, PA, USA Email: Dennis A Revicki* - Revicki@; Marc W Zodet - mzodet@; Sandra Joshua-Gotlib - ; Douglas Levine - ; Joseph A Crawley - * Corresponding author Published: 29 November 2003 Health and Quality of Life Outcomes 2003, 1:73 This. | BioMed Central Health and Quality of Life Outcomes Research Open Access Health-related quality of life improves with treatment-related GERD symptom resolution after adjusting for baseline severity Dennis A Revicki 1 Marc W Zodet2 Sandra Joshua-Gotlib3 Douglas Levine3 and Joseph A Crawley3 Address 1Center for Health Outcomes Research MEDTAP International Inc. Bethesda Maryland USA 2Agency for Health Research and Quality Rockville Maryland USA and 3AstraZeneca LP Wayne PA USA Email Dennis A Revicki - Revicki@ Marc W Zodet - mzodet@ Sandra Joshua-Gotlib - Douglas Levine - Joseph A Crawley - Corresponding author Published 29 November 2003 Received II August 2003 Accepted 29 November 2003 Health and Quality of Life Outcomes 2003 1 73 r This article is available from http content 1 1 73 2003 Revicki et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Severity and frequency of gastroesophageal reflux disease GERD related symptoms are associated with impaired health-related quality of life HRQL . This study evaluated the association between baseline heartburn severity and endpoint HRQL of patients treated for heartburn and the relationship between complete resolution of heartburn symptoms and HRQL outcomes after controlling for baseline severity. We completed a secondary analysis of clinical symptom and HRQL data from three clinical trials in adult patients receiving either omeprazole or ranitidine treatment for GERD. HRQL was assessed using the Psychological General Well-Being Index PGWB in each of the three clinical trials and two of the trials also included the Medical Outcomes Study Sleep disturbance scale. Gastrointestinal symptoms were evaluated using .