tailieunhanh - Health and Quality of Life Outcomes BioMed Central Research Open Access Quality of life in

Health and Quality of Life Outcomes BioMed Central Research Open Access Quality of life in multiple sclerosis: translation in French Canadian of the MSQoL-54 Catherine Acquadro*1, Louise Lafortune2 and Isabelle Mear1 Address: 1Mapi Research Institute, Lyon, France and 2Université de Montréal, Montréal, Quebec, Canada Email: Catherine Acquadro* - cacquadro@; Louise Lafortune - ; Isabelle Mear - imear@ * Corresponding author Published: 24 November 2003 Health and Quality of Life Outcomes 2003, 1:70 This article is available from: Received: 09 October 2003 Accepted: 24 November 2003 © 2003 Acquadro et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are. | BioMed Central Health and Quality of Life Outcomes Research Quality of life in multiple sclerosis translation in French Canadian of the MSQoL-54 Catherine Acquadro 1 Louise Lafortune2 and Isabelle Mear1 Open Access Address 1Mapi Research Institute Lyon France and 2Université de Montréal Montréal Quebec Canada Email Catherine Acquadro - cacquadro@ Louise Lafortune - Isabelle Mear- imear@ Corresponding author Published 24 November 2003 Received 09 October 2003 Accepted 24 November 2003 Health and Quality of Life Outcomes 2003 1 70 r This article is available from http content 1 1 70 2003 Acquadro et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background Multiple Sclerosis MS is a neurodegenerative disease which runs its course for the remainder of the patient s life frequently causing disability of varying degrees. Negative effects on Health-related quality of life HRQOL are well documented and a subject of clinical study. The Multiple Sclerosis QOL 54 MSQOL-54 questionnaire was developed to measure HRQOL in patients with MS. It is composed of 54 items and is a combination of the SF-36 and 18 diseasespecific items. Objective The objective of this project was to translate the MSQOL-54 into French Canadian and to make it available to the Canadian scientific community for clinical research and clinical practice. Methods Across all French speaking regions there are occurrences of variation. They include the pronunciation sentence structure and the lexicon where the differences are most marked. For this reason it was decided to translate the US original MSQOL-54 into French Canadian instead of adapting the existing French version. The SF-36 has been previously validated and published in French Canadian therefore the translation