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Health and Quality of Life Outcomes BioMed Central Research Open Access Brief assessment of priority symptoms in hormone refractory prostate cancer: The FACT Advanced Prostate Symptom Index (FAPSI) Susan Yount*1, David Cella1, Donald Banik1,2, Talat Ashraf3 and Daniel Shevrin4 Address: 1Center on Outcomes, Research and Education (CORE), Evanston Northwestern Healthcare and Northwestern University, 1001 University Place, Suite 100, Evanston, IL 60201 USA, 2University of New England College of Osteopathic Medicine, 11 Hills Beach Road, Biddeford, Maine 04005 USA, 3Abbott Laboratories, Dept. R42J, Building AP9A-2, 100 Abbott Park Road, Abbott Park, IL 60064-6124 USA and 4Evanston Northwestern Healthcare and Northwestern University, 2650 Ridge Avenue, Evanston, IL 60201. | BioMed Central Health and Quality of Life Outcomes Research Open Access Brief assessment of priority symptoms in hormone refractory prostate cancer The FACT Advanced Prostate Symptom Index FAPSI Susan Yount 1 David Cella1 Donald Banik1 2 Talat Ashraf3 and Daniel Shevrin4 Address 1Center on Outcomes Research and Education CORE Evanston Northwestern Healthcare and Northwestern University 1001 University Place Suite 100 Evanston IL 60201 USA 2University of New England College of Osteopathic Medicine 11 Hills Beach Road Biddeford Maine 04005 USA 3Abbott Laboratories Dept. R42J Building AP9A-2 100 Abbott Park Road Abbott Park IL 60064-6124 USA and 4Evanston Northwestern Healthcare and Northwestern University 2650 Ridge Avenue Evanston IL 60201 USA Email Susan Yount - s-yount@ David Cella - d-cella@ Donald Banik - dbanik@ Talat Ashraf - Daniel Shevrin - d-shevrin@ Corresponding author Published 21 November 2003 Received 25 July 2003 Accepted 21 November 2003 Health and Quality of Life Outcomes 2003 1 69 r This article is available from http content 1 1 69 2003 Yount et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background The objective of this study was to construct and validate a brief clinically-relevant symptom index for advanced prostate cancer. Methods Questions were extracted from a commonly-used multi-dimensional cancer quality of life instrument with prostate-specific items the Functional Assessment of Cancer Therapy-Prostate FACT-P . Surveys of disease-related symptoms were presented to an international sample of 44 expert physicians. Each expert narrowed the list to no more than five of the most important symptoms or concerns to monitor when assessing the value of .