tailieunhanh - Báo cáo y học: "Cardiac arrest provoked by itraconazole and amiodarone interaction: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Cardiac arrest provoked by itraconazole and amiodarone interaction: a case report. | Tsimogianni et al. Journal of Medical Case Reports 2011 5 333 http content 5 1 333 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Cardiac arrest provoked by itraconazole and amiodarone interaction a case report Angeliki M Tsimogianni Ilias Andrianakis Alex Betrosian and Emmanouil Douzinas Abstract Introduction Azoles and specifically itraconazole are often prescribed for the treatment of fungal diseases or empirically for persistent sepsis in patients who are neutropenic or in intensive care. Occasional cardiovascular adverse events have been associated with itraconazole use and are usually attributed to the interaction of itraconazole with cisapride terfenadine or digoxin. Its interaction with amiodarone has not been previously described. Case presentation A 65-year-old Caucasian man was admitted to the Intensive Care Unit at our facility for an extensive ischemic stroke associated with atrial fibrillation. Due to rapid ventricular response he was started on intravenous amiodarone and few days later itraconazole was also prescribed for presumed candidemia. After receiving the first dose our patient became profoundly hypotensive but responded rapidly to fluids and adrenaline. Then two months later itraconazole was again prescribed for confirmed fungemia. After receiving the first dose via a central venous catheter our patient became hypotensive and subsequently arrested. He was resuscitated successfully and as no other cause was identified the arrest was attributed to septic shock and his antifungal treatment was changed to caspofungin. When sensitivity test results became available antifungal treatment was down-staged to itraconazole and immediately after drug administration our patient suffered another arrest and was once again resuscitated successfully. This time the arrest was related to itraconazole which was discontinued and from then on our patient remained stable until his discharge to our neurology ward. Conclusions .