tailieunhanh - Báo cáo y học: "F-fluorodeoxyglucose positron emission tomography-positive sarcoidosis after chemoradiotherapy for Hodgkin’s disease: a case report."

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: F-fluorodeoxyglucose positron emission tomography-positive sarcoidosis after chemoradiotherapy for Hodgkin’s disease: a case report. | Cherk et al. Journal of Medical Case Reports 2011 5 247 http content 5 1 247 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access 18F-fluorodeoxyglucose positron emission tomography-positive sarcoidosis after chemoradiotherapy for Hodgkin s disease a case report Martin H Cherk1 3 Alan Pham2 and Andrew Haydon3 Abstract Introduction The occurrence of granulomatous disease in the setting of Hodgkin s disease is rare however when it occurs it can pose significant clinical and diagnostic challenges for physicians treating these patients. Case presentation We report the case of a 33-year-old Caucasian woman of Mediterranean descent with newly diagnosed 18F-fluorodeoxyglucose 18F-FDG positron emission tomography PET computed tomography CT scanpositive early-stage Hodgkin s disease involving the cervical nodes who despite having an excellent clinical response to chemotherapy had a persistent 18F-FDG PET scan-positive study which was suggestive of residual or progressive disease. A subsequent biopsy of her post-chemotherapy PET-positive nodes demonstrated sarcoidosis with no evidence of Hodgkin s disease. Conclusion This case highlights the fact that abnormalities observed on posttherapy PET CT scans in patients with Hodgkin s disease are not always due to residual or progressive disease. An association between Hodgkin s disease and or its treatment with an increased incidence of granulomatous disease appears to exist. Certain patterns of 18F-FDG uptake observed on PET CT scans may suggest other pathologies such as granulomatous inflammation and because of the significant differences in prognosis and management clinicians should maintain a low threshold of confidence for basing their diagnosis on histopathological evaluations when PET CT results appear to be incongruent with the patient s clinical response. Introduction The use of positron emission tomography PET com-puted tomography CT to evaluate lymphoma including Hodgkin s disease .