tailieunhanh - Báo cáo y học: "Sustained eradication of hepatitis C virus by low-dose long-term interferon therapy in a renal transplant recipient with dual infection with hepatitis B and C viruses: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Sustained eradication of hepatitis C virus by low-dose long-term interferon therapy in a renal transplant recipient with dual infection with hepatitis B and C viruses: a case report. | Chang et al. Journal of Medical Case Reports 2011 5 246 http content 5 1 246 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Sustained eradication of hepatitis C virus by low-dose long-term interferon therapy in a renal transplant recipient with dual infection with hepatitis B and C viruses a case report Ming-Ling Chang1 Ping-Chin Lai2 and Chau-Ting Yeh3 Abstract Introduction Accelerated liver function deterioration has been recognized in renal transplant recipients infected with hepatitis C virus HCV . Although combination therapy with interferon plus ribavirin has been established as the standard treatment for patients with chronic HCV the high risk of allograft rejection associated with interferon therapy has greatly discouraged the clinical use of this regimen. In Asia where chronic hepatitis B virus HBV is prevalent dual infection with HBV and HCV poses an even greater challenge for clinical hepatologists. Case presentation In this article we report the case of a 51-year-old Taiwanese man with dual infection with HBV and HCV prior to renal transplantation. Low-dose interferon 3 to 6 X 106 U week and ribavirin 100 mg day to 200 mg day were prescribed following the reactivation of the man s HCV after renal transplantation. Additionally lamivudine 100 mg day was administered concomitantly to prevent HBV reactivation. His initial serum HCV RNA concentration was X 106 copies mL genotype 2a . After three and one-half years of antiviral therapy his HCV was successfully eradicated without any episodes of allograft rejection. His serum HCV RNA remained negative six months after withdrawal from interferon and ribavirin treatment. His serum HBV DNA remained undetectable throughout the course of therapy. Conclusion Low-dose long-term interferon therapy may achieve sustained eradication of HCV in the renal transplant recipient with dual infection with HBV and HCV. Introduction Chronic hepatitis C virus HCV infection may lead to .