tailieunhanh - Báo cáo y học: "Fibrous dysplasia of bone associated with softtissue myxomas as well as an intra-osseous myxoma in a woman with Mazabraud’s syndrome: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Fibrous dysplasia of bone associated with softtissue myxomas as well as an intra-osseous myxoma in a woman with Mazabraud’s syndrome: a case report. | van der Wal et al. Journal of Medical Case Reports 2011 5 239 http content 5 1 239 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Fibrous dysplasia of bone associated with soft-tissue myxomas as well as an intra-osseous myxoma in a woman with Mazabraud s syndrome a case report lAA Hroro A co dor A ol1 doll I InoI2 ìC b A I do Roov3 I Ifo Ph li-lvo4 ood Rooo PI I oth5 vvyuiell A van del vval Halil nal Jacky WJ de Rooy Uta Flucke and nene PH Veth Abstract Introduction Mazabraud s syndrome is a rare but well-described disorder characterized by fibrous dysplasia in single or multiple bones associated with one or more soft-tissue myxomas. In this report we describe what is to the best of our knowledge the first case involving an intra-osseous myxoma. This finding supports and could provide new insight into the pathological association between fibrous dysplasia and myxomas. Case presentation In this report we describe the case of a 49-year-old Caucasian woman known for years to have fibrous dysplasia in the left femur and tibia who presented with progressive pain in her left leg and soft swelling in the left quadriceps region. After surgical intervention with excision of the soft-tissue mass the diagnosis of Mazabraud s syndrome was confirmed. During follow-up our patient presented with a painless mass located on the lateral side of the left knee next to a second intra-osseous lesion with the same characteristics in the left lateral tibial plateau. The histopathological examination was consistent with a soft-tissue intra-osseous myxoma. Conclusion In the international literature 67 cases of Mazabraud s syndrome have been described so far. To our knowledge the present case report is the first to describe the combination of polyostotic fibrous dysplasia and intra-muscular as well as intra-osseous myxoma. Introduction Mazabraud s syndrome is a rare but well-described disorder. It is characterized by fibrous dysplasia which can develop in