tailieunhanh - Báo cáo y học: "Giant mediastinal mature teratoma with increased exocrine pancreatic activity presenting in a young woman: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Giant mediastinal mature teratoma with increased exocrine pancreatic activity presenting in a young woman: a case report. | Stella and Davoli Journal of Medical Case Reports 2011 5 238 http content 5 1 238 JOURNALOF medical LrCASE REPORTS CASE REPORT Open Access Giant mediastinal mature teratoma with increased exocrine pancreatic activity presenting in a young woman a case report Franco Stella and Fabio Davoli Abstract Introduction Mediastinal mature teratoma is a benign slow-growing tumor typically affecting 20- to 40-year-old adults. Fluid examination from the cystic masses rarely shows enzymatic activity as we describe in this report. Case presentation We report a case of a giant mediastinal germ cell tumor measuring 15 cm X 14 cm X 8 cm detected in a 35-year-old Caucasian woman. Microscopic examination showed that the lesion resembled a mature cystic teratoma with areas of pancreatic tissue with mature ductal and acinar structures intermixed with islets of Langerhans. Fluid from the cysts in the mass was examined after removal showed amylase activity of 599 U l despite normal serum levels. The post-operative period was free of complications and the patient was discharged on post-operative day 10. Conclusion Complete surgical removal is the treatment of choice for mature cystic teratomas with optimal results and acceptable surgical risk. Exocrine pancreatic function may be an aid to pre-operative or intra-operative diagnosis however these findings have no impact on survival or the therapeutic pathway. Introduction Primary germ cell tumors GCTs of the mediastinum are rare tumors 10 to 15 of all mediastinal tumors and they usually appear during the third to fourth decade of life 1 . GCTs are predominantly found in gonads and the anterior mediastinum is the common extragonadal site 2 . The majority of mediastinal teratomas are mature teratomas that are histologically well-defined and benign 3 . Malignant GCTs account for less than 1 of all mediastinal tumors and mature teratomas account for approximately 8 1 . Case report We present a case of a giant mature .