tailieunhanh - Báo cáo y học: "Fatal invasive cervical cancer secondary to untreated cervical dysplasia: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Fatal invasive cervical cancer secondary to untreated cervical dysplasia: a case report. | Braun et al. Journal of Medical Case Reports 2011 5 316 http content 5 1 316 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Fatal invasive cervical cancer secondary to untreated cervical dysplasia a case report 1112 1 1 Stephan Braun Daniel Reimer Isolde Strobl Ulrike Wieland Petra Wiesbauer Elisabeth Muller-Holzner Siegfried Fessler1 Arthur Scherer3 Christian Marth1 and Alain G Zeimet1 Abstract Introduction Well-documented cases of untreated cervical intra-epithelial dysplasia resulting in fatal progression of invasive cervical cancer are scarce because of a long pre-invasive state the availability of cervical cytology screening programs and the efficacy of the treatment of both pre-invasive and early-stage invasive lesions. Case presentation We present a well-documented case of a 29-year-old Caucasian woman who was found through routine conventional cervical cytology screening to have pathologic Papanicolaou Pap grade III D lesions squamous cell abnormalities . She subsequently died as a result of human papillomavirus type 18-associated cervical cancer after she refused all recommended curative therapeutic procedures over a period of 13 years. Conclusion This case clearly demonstrates a caveat against the promotion and use of complementary alternative medicine as pseudo-immunologic approaches outside evidence-based medicine paths. It also demonstrates the impact of the individualized demands in diagnosis treatment and palliative care of patients with advanced cancer express their will to refuse evidence-based treatment recommendations. Introduction Cases of intra-epithelial disease of the cervix are almost entirely attributable to human papillomavirus HPV infection. A minority of women exposed to HPV develop a persistent infection that affects the squamocolumnar junction where the ectocervix and endocervix meet. Within that junction dynamic changes of the epithelium occur due to puberty pregnancy menopause and hormonal .