tailieunhanh - Báo cáo y học: " Implication of human papillomavirus-66 in vulvar carcinoma: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Implication of human papillomavirus-66 in vulvar carcinoma: a case report. | Kotsopoulos et al. Journal of Medical Case Reports 2011 5 232 http content 5 1 232 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Implication of human papillomavirus-66 in vulvar carcinoma a case report 1 1 1 2 loannis C Kotsopoulos Georgios P Tampakoudis Dimitrios G Evaggelinos Anastasia I Nikolaidou Panagiota A Fytili3 Vasilios C Kartsiounis 1 and Domniki K Gerasimidou2 Abstract Introduction Vulvar cancer in older women is seldom associated with human papillomavirus infection. Case presentation We present the case of an 80-year-old Greek Caucasian woman with an undetermined obstetric and gynecologic history. The patient underwent radical vulvectomy and bilateral inguinal lymphadenectomy for a vulvar carcinoma. A human papillomavirus infection was suggested on the basis of histological and cytological examinations followed by human papillomavirus DNA typing which revealed the presence of human papillomavirus-66. Conclusion Even though human papillomavirus-16 and human papillomavirus-18 are most frequently implicated in the pathogenesis of vulvar carcinoma human papillomavirus-66 can also be regarded as a causative factor. Suspicious lesions should be biopsied and in the presence of carcinoma vulvectomy with bilateral lymphadenectomy if necessary must be performed. Furthermore polymerase chain reaction assay analysis with clinical arrays in cytological samples is an accurate test for the detection of a wide range of human papillomavirus genotypes and can be used to verify the infection and specify the human papillomavirus type implicated. Introduction Vulvar carcinoma in older women is seldom associated with any type of human papillomavirus HPV infection representing less than 15 of reported cases 1 . Atypia of the squamous epithelium of the vulva is considered to be a co-factor in the carcinogenesis of vulvar cancer and usually a non-neoplastic lesion such as vulvar inflammation lichen sclerosus or hyperplasia of squamous .