tailieunhanh - Báo cáo y học: "Henoch Schönlein purpura associated with pulmonary adenocarcinoma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Henoch Schönlein purpura associated with pulmonary adenocarcinoma. | Mifune et al. Journal of Medical Case Reports 2011 5 226 http content 5 1 226 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Henoch Schonlein purpura associated with pulmonary adenocarcinoma 1 1 11 1 1 Daiki Mifune Satoshi Watanabe Rie Kondo Yoko Wada Hiroshi Moriyama Hiroshi Kagamu Hirohisa Yoshizawa2 Takafumi Tetsuka3 Asako Matsuyama4 Kaoru Ito4 and Ichiei Narita1 Abstract Introduction Henoch-Schonlein purpura is a common immunoglobulin A-mediated vasculitis syndrome in children. Henoch-Schonlein purpura can also affect adults and is probably related to malignancy. Case presentation We report the case of a 61-year-old Japanese man who presented for examination after an abnormal shadow was detected by chest radiography. He received a diagnosis of pulmonary adenocarcinoma stage IV. Purpura on the legs abdominal pain diarrhea hematuria and proteinuria developed at this time. Henoch-Schonlein purpura was diagnosed base on the clinical symptoms and histological findings of biopsy specimens of the skin which showed vasculitis with immunoglobulin A deposits. Our patient received chemotherapy with gemcitabine after successful steroid therapy for the Henoch-Schonlein purpura. Conclusion Although hematological malignancies are well-known causes of vasculitides cases of Henoch-Schonlein purpura associated with lung adenocarcinoma are rare. Our patient was treated with corticosteroid therapy which cleared the purpura and cytotoxic chemotherapy for the non-small cell lung cancer. However he died from heart failure due to cardiac tamponade. Introduction Henoch-Schonlein Purpura HSP is a systemic vasculitis that involves the small vessels most notably those in the skin gastrointestinal tract and glomeruli and is accompanied by arthralgia or arthritis 1 . HSP occurs commonly in children but can also affect adults 2 . Although the exact cause of HSP remains unknown malignancy has been reported as a causative factor 3-5 . This report .