tailieunhanh - Báo cáo y học: "Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation. | Available online http content 11 5 R133 Research article Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation Tilo Dehne1 Camilla Karlsson2 Jochen Ringe1 Michael Sittinger1 and Anders Lindahl2 Tissue Engineering Laboratory and Berlin-Brandenburg Center for Regenerative Therapies Department of Rheumatology and Clinical Immunology Charite-Universitatsmedizin Berlin TucholskystraBe 2 Berlin 10117 Germany institute of Laboratory Medicine Department of Clinical Chemistry and Transfusion Medicine Sahlgrenska University Hospital Bruna Straket 16 Gothenburg SE 413-45 Sweden Contributed equally Corresponding author Tilo Dehne Received 16 Mar 2009 Revisions requested 20 Apr 2009 Revisions received 27 Jul 2009 Accepted 2 Sep 2009 Published 2 Sep 2009 Arthritis Research Therapy 2009 11 R133 doi 86 ar2800 This article is online at http content 11 5 R133 2009 Dehne et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Autologous chondrocyte transplantation ACT is a routine technique to regenerate focal cartilage lesions. However patients with osteoarthritis OA are lacking an appropriate long-lasting treatment alternative partly since it is not known if chondrocytes from OA patients have the same chondrogenic differentiation potential as chondrocytes from donors not affected by OA. Methods Articular chondrocytes from patients with OA undergoing total knee replacement Mankin Score 3 Ahlback Score 2 and from patients undergoing ACT here referred to as normal donors ND were isolated applying protocols used for ACT. Their chondrogenic .