tailieunhanh - Báo cáo y học: "Osteoarthritis associated with estrogen deficiency"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Osteoarthritis associated with estrogen deficiency. | Available online http content 11 5 241 Review Osteoarthritis associated with estrogen deficiency Jorge A Roman-Blas1 2 Santos Castaneda3 Raquel Largo1 and Gabriel Herrero-Beaumont1 1 Bone and Joint Research Unit Service of Rheumatology Fundacion Jimenez Díaz Universidad Autónoma Madrid 28040 Spain 2Jefferson Institute of Molecular Medicine Thomas Jefferson University Philadelphia 19107 USA 3Department of Rheumatology Hospital de la Princesa Universidad Autónoma Madrid 28005 Spain Corresponding author Gabriel Herrero-Beaumont gherrero@ Published 21 September 2009 This article is online at http content 11 5 241 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 241 doi ar2791 Abstract Osteoarthritis OA affects all articular tissues and finally leads to joint failure. Although articular tissues have long been considered unresponsive to estrogens or their deficiency there is now increasing evidence that estrogens influence the activity of joint tissues through complex molecular pathways that act at multiple levels. Indeed we are only just beginning to understand the effects of estrogen deficiency on articular tissues during OA development and progression as well as on the association between OA and osteoporosis. Estrogen replacement therapy and current selective estrogen receptor modulators have mixed effectiveness in preserving and or restoring joint tissue in OA. Thus a better understanding of how estrogen acts on joints and other tissues in OA will aid the development of specific and safe estrogen ligands as novel therapeutic agents targeting the OA joint as a whole organ. Introduction Osteoarthritis OA is a very common chronic disease that affects all joint tissues causing progressive irreversible damage and finally the failure of the joint as an organ 1 . Characteristic pathological changes in OA not only include joint cartilage degeneration but also subchondral bone thickening osteophyte .