tailieunhanh - Báo cáo y học: "Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems. | Available online http content 11 5 125 Editorial Anticitrullinated protein peptide antibodies and rheumatoid factors two distinct autoantibody systems Guido Valesini and Cristiano Alessandri Dipartimento di Clinica e Terapia Medica Reumatologia Sapienza Università di Roma del Policlinico 155 00161 Rome Italy Corresponding author Guido Valesini Published 14 September 2009 Arthritis Research Therapy 2009 11 125 doi ar2786 This article is online at http content 11 5 125 2009 BioMed Central Ltd See related research by Ursum et al. http content 11 3 R75 Abstract In a previous issue of Arthritis Research and Therapy Ursum and colleagues report the relative stabilities of anticitrullinated protein peptide antibodies ACPAs and IgM rheumatoid factors during the course of rheumatoid arthritis and their differential correlation with markers of the acute-phase response. These findings add to a growing body of evidence highlighting the distinct nature of these two autoantibody systems and the role of ACPAs as a diseasespecific marker of rheumatoid arthritis. In a previous issue of Arthritis Research and Therapy Ursum and colleagues report data showing that the anticitrullinated protein peptide antibody ACPA status is significantly more stable than that of IgM rheumatoid factors RFs during the course of rheumatoid arthritis RA 1 - a finding that is fully consistent with previous reports 2 . They also found that the frequency of ACPA positivity is unrelated to age in RA patients and in the few ACPA-positive patients with non-RA disease whereas RF positivity displayed age-related increases in patients with non-RA disease and it was also more closely correlated with acute-phase inflammatory markers. These findings which are based on serological studies in over 18 000 patients attending outpatient rheumatology clinics add to a steadily growing body of evidence highlighting .