tailieunhanh - Báo cáo y học: "Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes. | Available online http content 11 4 R119 Research article Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes Steeve Kwan Tat1 Jean-Pierre Pelletier1 Nathalie Amiable1 Christelle Boileau1 Martin Lavigne2 and Johanne Martel-Pelletier1 Open Access Osteoarthritis Research Unit University of Montreal Hospital Research Centre CRCHUM Notre-Dame Hospital 1560 Sherbrooke Street East Montreal Quebec H2L 4M1 Canada 2Department of Orthopaedic Surgery Maisonneuve-Rosemont Hospital 5345 boulevard l Assomption Montreal Quebec H1T 4B3 Canada Corresponding author Johanne Martel-Pelletier jm@ Received 17 Mar 2009 Revisions requested 1 May 2009 Revisions received 6 Jul 2009 Accepted 7 Aug 2009 Published 7 Aug 2009 Arthritis Research Therapy 2009 11 R119 doi 86 ar2782 This article is online at http content 11 4 R119 2009 Kwan Tat et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Members of the ephrin system the ephrin receptor erythropoietin-producing hepatocellular B4 EphB4 and its specific ligand ephrin B2 appear to be involved in the bone remodelling process. We recently showed that their interaction inhibits the resorptive activity of human osteoarthritic OA subchondral bone osteoblasts. Hence we further investigated the possible implication of these ephrin members on the catabolic anabolic activities of human OA chondrocytes. Methods EphB4 receptor and ephrin B2 levels were determined by quantitative PCR and immunohistochemistry and the effects of ephrin B2 on the expression production of factors involved in the OA process. Results EphB4 receptors and ephrin B2 ligands are expressed and .