tailieunhanh - Báo cáo y học: "Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study. | Available online http content 11 4 R110 Research article Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect A cross sectional study Tracey E Toms1 2 Vasileios F Panoulas1 Holly John1 Karen MJ Douglas1 and George D Kitas1 2 Department of Rheumatology Dudley Group of Hospitals NHS Trust Russells Hall Hospital Dudley West Midlands DY1 2HQ UK 2ARC Epidemiology Unit Manchester University Oxford Road Manchester M13 9PT UK Corresponding author George D Kitas Received 1 Apr 2009 Revisions requested 11 May 2009 Revisions received 22 Jun 2009 Accepted 1 6 Jul 2009 Published 16 Jul 2009 Arthritis Research Therapy 2009 11 R110 doi 86 ar2765 This article is online at http content 11 4 R110 2009 Toms et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The metabolic syndrome MetS may contribute to the excess cardiovascular burden observed in rheumatoid arthritis RA . The prevalence and associations of the MetS in RA remain uncertain systemic inflammation and anti-rheumatic therapy may contribute. Methotrexate MTX use has recently been linked to a reduced presence of MetS via an assumed generic anti-inflammatory mechanism. We aimed to assess the prevalence of the MetS in RA identify factors that associate with its presence and assess their interaction with the potential influence of MTX. Methods MetS prevalence was assessed cross-sectionally in 400 RA patients using five MetS definitions National Cholesterol Education Programme 2004 and 2001 International Diabetes Federation World Health Organisation and .