tailieunhanh - Báo cáo khoa học: "Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series. | Pak Journal of Medical Case Reports 2011 5 296 http content 5 1 296 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells a case series Jaewoo Pak Abstract Introduction This is a series of clinical case reports demonstrating that a combination of percutaneously injected autologous adipose-tissue-derived stem cells hyaluronic acid platelet rich plasma and calcium chloride may be able to regenerate bones in human osteonecrosis and with addition of a very low dose of dexamethasone cartilage in human knee osteoarthritis. Case reports Stem cells were obtained from adipose tissue of abdominal origin by digesting lipoaspirate tissue with collagenase. These stem cells along with hyaluronic acid platelet rich plasma and calcium chloride were injected into the right hip of a 29-year-old Korean woman and a 47-year-old Korean man. They both had a history of right hip osteonecrosis of the femoral head. For cartilage regeneration a 70-year-old Korean woman and a 79-year-old Korean woman both with a long history of knee pain due to osteoarthritis were injected with stem cells along with hyaluronic acid platelet rich plasma calcium chloride and a nanogram dose of dexamethasone. Pre-treatment and post-treatment MRI scans physical therapy and pain score data were then analyzed. Conclusions The MRI data for all the patients in this series showed significant positive changes. Probable bone formation was clear in the patients with osteonecrosis and cartilage regeneration in the patients with osteoarthritis. Along with MRI evidence the measured physical therapy outcomes subjective pain and functional status all improved. Autologous mesenchymal stem cell injection in conjunction with hyaluronic acid platelet rich plasma and calcium chloride is a promising minimally invasive therapy for osteonecrosis of femoral head .

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