tailieunhanh - Báo cáo y học: "Rheumatoid arthritis and smoking: putting the pieces together"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Rheumatoid arthritis and smoking: putting the pieces together. | Available online http content 11 4 238 Review Rheumatoid arthritis and smoking putting the pieces together Zsuzsanna Baka1 Edit Buzas1 and Gyorgy Nagy1 2 1 Department of Genetics Cell and Immunobiology Semmelweis University Nagyvárad tér 4. Budapest H-1445 Hungary 2Department of Rheumatology Semmelweis University Árpád fejedelem útja 7. Budapest H-1023 Hungary Corresponding author Gyorgy Nagy gyorgyngy@ Published 3 August 2009 This article is online at http content 11 4 238 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 238 doi ar2751 Abstract Besides atherosclerosis and lung cancer smoking is considered to play a major role in the pathogenesis of autoimmune diseases. It has long been known that there is a connection between rheumatoid factor-positive rheumatoid arthritis and cigarette smoking. Recently an important gene-environment interaction has been revealed that is carrying specific HLA-DRB1 alleles encoding the shared epitope and smoking establish a significant risk for anti-citrullinated protein antibody-positive rheumatoid arthritis. We summarize how smoking-related alteration of the cytokine balance the increased risk of infections the possibility of cross-reactivity and modifications of autoantigens by citrullination may contribute to the development of rheumatoid arthritis. Introduction It has long been known that there is a connection between seropositive rheumatoid arthritis RA and smoking. The exact underlying mechanism however has only been speculated. Cigarette smoking is one of the major environmental factors suggested to play a crucial role in the development of several diseases. Disorders affecting the great portion of the population such as atherosclerosis lung cancer or cardiovascular diseases are highly associated with tobacco consumption. More recently it has been reported that smoking is involved in the pathogenesis of certain autoimmune diseases such as RA systemic .